18th International Conference on Neonatal & Childhood Pulmonary Vascular Disease

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March 27 - 29, 2025
Hilton San Francisco Financial District • San Francisco, CA
Course# MPD25002 - Department: Pediatrics

 


 

Overview

Over the past decade, great strides have been made in our understanding of the pathobiology of pulmonary vascular disease, and from these findings new therapeutic options have emerged. It is increasingly clear that pulmonary vascular pathology is integral to a number of childhood disorders. In this symposium, we will bring together international experts to explore our current understanding of the basic pathobiology as well as new and future therapies for neonatal, pediatric, and adult pulmonary vascular diseases.

Target Audience
Pediatric and Adult Pulmonologists, Cardiology and Critical Care Physicians, Neonatology Physicians, and Advanced Practice Nurses.

Objectives

Upon completion of this activity, attendees will have improved skills and strategies to:

  • Utilize treatment delivery systems effectively based on past, current, and future therapeutics for neonatal and childhood pulmonary vascular disease;
  • Apply new knowledge of the developmental vascular biology of neonatal pulmonary vascular disease to increase early detection of the pathology in infants;
  • Evaluate the new treatment modalities and the latest science behind these advances;
  • Recognize rare forms of pediatric PVD;
  • Learn the latest imaging modalities for the right ventricle;
  • Facilitate diagnosis and treatment choices using genetic testing;
  • Understand the latest clinical and basic science updates of pulmonary vascular disease.

Accreditation

In support of improving patient care, the University of California, San Francisco is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians: UCSF designates this live activity for a maximum of 22.75 AMA PRA Category 1 CreditsTMPhysicians should claim only the credit commensurate with the extent of their participation in the activity. 

This CME activity meets the requirements under California Assembly Bill 1195, continuing education and cultural and linguistic competency. 

Nurse Practitioners and Registered Nurses: For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA Category 1 CreditsTM issued by organizations accredited by the ACCME. This course is also available for 16.00 Nurse Contact Hours as designated by the ANCC.   

Physician Assistants: The National Commission on Certification of Physician Assistants (NCCPA) states that AMA PRA Category 1 CreditsTM are acceptable for continuing medical education requirements for recertification.

Course Outline

Times listed are Pacific Time

View Workshop Agenda: Thursday, March 27, 2025

 Download Workshop Agenda

 THURSDAY, MARCH 27, 2025 
7:30amRegistration | Continental Breakfast | Exhibits Open 
   
7:55Welcome and IntroductionDrs. Abman, Austin, and Fineman
   
8:00Setting the Stage: Interdisciplinary Care of the Infant and Young Child with PH Associated with Developmental Lung Disorders (a subtype of Group 3 PH)Nidhy P. Varghese, MD
   
 SESSION 1: Normal, Abnormal, and Repaired Cardiopulmonary DevelopmentModerators: Roberta L. Keller and David Cornfield
   
8:30Role of FOXF1 in the pathobiology of PAH: From serendipity to discoveryJose Gomez-Arroyo, MD, PhD
   
9:00Defining the Typical Course of Persistent Pulmonary Hypertension of the Newborn: What Characterizes an Atypical Course?Stephanie M. Tsoi, MD 
   
9:30Break | Exhibits 
   
 SESSION 2: Features and Modulation of the Lung Microenvironment Across the LifespanModerators: Jeffrey Whitsett, MD and Cristina Alvira, MD
   
9:50Familial Experience with a Rare Lung Disease Diagnosis, Syndrome Recognition, and Formation of Disease-Targeted Foundation Anton Morkin, Founder and CEO, TBX4Life
   
10:20Introduction: TBX4Life Lecture (RECORDED)Eric D. Austin, MD, MSc
   
10:25The TBX4Life Lecture: “Is Adult PAH a Pediatric Disease?” Transcriptional Programs That Orchestrate Fetal Lung Development Reactivate in Adult PAH Patient-Derived Lung CellsSoni S. Pullamsetti, PhD – TBX4 Life
   
11:00Lung Microenvironment’s Modulation of Gene Transcription Across the Lifespan Lance S. Prince, MD
   
11:30Lunch on your own 
   
 SESSION 3: Therapeutic Approaches to Target Pulmonary Vascular Disease, Lung Protection and Regeneration: What is Possible and Where Are We Headed?Moderators: Steven H. Abman and Bernard Thébaud
   
1:00Beyond “Possible”: In Utero Gene Therapy for Developmental and Other DiseasesTippi MacKenzie, MD
   
1:30Mesenchymal Cell Therapy Trial to Heal the Lungs of Preterm InfantsBernard Thébaud, MD 
   
2:00Gene Therapy and Drug Delivery Precisely to the Lung Microvascular Endothelium as a Treatment for Pulmonary Vascular DiseasesVladimir Kalinichenko, MD, PhD
   
2:30Break | Exhibits 
   
2:40Generation of Induced Pluripotent Stem Cells to Develop Individualized Drug Therapeutic ApproachesDarrell N. Kotton, MD
   
3:10Known Drugs Doing New Things: Repurpose of Existing Drug Therapies to Treat Pulmonary Vascular Diseases Edda Spiekerkoetter, MD
   
3:40Lung Development, Repair, Regeneration, and Potential for Therapeutic DevelopmentEdward E. Morrisey, PhD
   
4:10Rare Inform the Common: Preserving Vascular Development for the Prevention and Treatment of Neonatal PHSteven H. Abman, MD
   
4:40Group Discussion 
   
5:00Adjourn 
View General Session Agenda: Friday - Saturday, March 28-29, 2025

 Download General Session Agenda

FRIDAY, MARCH 28, 2025
 7:00 am Registration | Continental Breakfast | Exhibits
 7:45 Welcome and Opening Remarks
SESSION 1: NEONATAL PULMONARY VASCULAR DISEASE
MODERATORS: Drs. Roberta Keller and Bernard Thébaud
8:00-8:30A perspective on neonatology-led and multidisciplinary teams in the management of pulmonary hypertension in the NICU
 Dr. Gabriel Altit
8:30-9:00iPSC-derived lung vascular endothelial cells and the influence of preeclamptic placental signaling on the pulmonary endothelium
 Dr. Elizabeth Taglauer
9:00-9:30Owen McKinnon Lecture Presented by Dr. Steven Abman
 ACD/MPV/TBX4 pulmonary vascular formation and PAH
 Dr. Jeff Whitsett
9:30-9:45 Break
SESSION 2: SPECIAL TOPICS
MODERATORS: Drs. Cookson and Smith
9:45-10:30AI In Pulmonary Hypertension
 Dr. Cedric Manlhiot 
10:30-11:15Health Disparities in PVD
 Dr. Vinicio de Jesus Perez 
THE ROBYN BARST KEYNOTE LECTURE
11:20Introduction: The Robyn Barst Keynote Lecture
 Dr. Steven Abman
11:30KEYNOTE SPEAKER: The Robyn Barst Keynote Lecture: My Journey in Academic Pulmonary Hypertension
 Dr. Maria del Cerro
12:30 PMLunch on your own
SESSION 2: Uncommon Pediatric PH Challenges
MODERATORS: Drs. Usama Kanaan and Russel Hirsch
2:00-2:30Complex congenital heart disease: TGA
 Dr. Dunbar Ivy
2:30-3:00Immunologic disorders and PH
 Dr. Roham Zamanian 
3:00-3:30Sickle Cell Disease: An Update
 Dr. Roberto Machado 
3:30-4:00Portopulmonary Hypertension
 Dr. Maurice Beghetti
4:00-4:15Break/Exhibits
4:15-4:45New Drug Pediatric/Adult Experience: Sotatercept
 Paul Critser/Marc Simon/Maurice Beghetti 
4:45-5:15Group Discussion
5:15-6:15PHuzzlers
 Drs. Handler, Varghese, Berman-Rosenzweig
6:15 PMAdjourn
  
SATURDAY, MARCH 29, 2025
 6:30 am Continental Breakfast | Exhibits
7:00Sunrise Discussions in the Grand Ballroom: Moderator:  Drs. Russel Hirsch
 Touched by PH: Less Common Syndromes in Pediatric PH
1. Post Cardiopulmonary Bypass Pulmonary Hypertension in Pediatrics
Dr. John Berger
2. Inflammatory Syndromes in Pediatric Pulmonary Hypertension
Dr. Liezl Domingo
3. Liver Failure / Portal Vein Abnormalities in Pediatric Pulmonary Hypertension
Dr. Amanda Hauck
4. Drug Induced Pulmonary Hypertension in Pediatrics
Dr. Kinjal Parikh
SESSION 3: Imaging of the RV in PVD
MODERATORS: Drs. Hythem Nawaytou, Shahin Moledina, and Mark Friedberg
8:00-8:20Should TAPSE still be used as a key measure of RV function? The pros and cons.
 Dr. Amanda Hauck
8:20-8:40RV diastolic dysfunction impacts outcomes, but can we really diagnose it without cath?
 Dr. Mark Friedberg 
8:40-9:00We don’t routinely assess ventricular-arterial coupling in the left heart, so should we assess it on the right? And if so, how?
 Dr. Kimberly Miles (recorded)
9:00-9:20Hope or hype: Assessment of RV strain in PH.
 Dr. Hythem Nawaythou
9:20-9:40MRI for PH:  Where we are and where we are going.
 Dr. Shahin Moledina
9:40-10:00Panel Discussion
10:00-10:15Break | Exhibits
SESSION 4: SCIENTIFIC SESSION INCLUDING ABSTRACT POSTER SYMPOSIUM 
MODERATORS: Drs. Datar and Raj
10:15-11:15Poster Viewing (Authors Present at Posters)
11:15-11:45The Year in Review: Basic Science
 Dr. Usha Raj
11:45-12:15The Year in Review: Clinical Science
 Dr. Erika Rosenzweig
12:15-12:45Update from the World Symposium
 Dr. Rolf Berger
12:45 PMLunch on your own
2:15 PMPlatform Sessions: Brief Poster Oral Discussions
 Lucas Van wormer Presentation:
 Dr. Dunbar Ivy
2:15-2:30Scientific Presentation #1 – The Lucas van Wormer Awardee
 Kaylie Chiles
2:30-2:45Scientific Presentation #2 – Autoimmunity in Pediatric PAH
 Dr. Aaron Bodansky
2:45-3:00Scientific Presentation #3 – Developing a Pediatric PH Risk Model
 Dr. Megan Griffiths
SESSION 5: High Output Pulmonary Vascular Disease
MODERATOR: Drs. Usha Krishnan and Mary Mullen
3:00-3:30pmVein of Galen Malformations: Hemodynamics
 Dr. Phil Levy
3:30-4:00Vein of Galen: Interventions
 Dr. Darren Orbach – Recorded
4:00-4:30HHT-PH
 Dr. Edda Spiekerkoetter
4:30-5:00Panel discussion and Q&A
5:00 PMClosing Remarks and Adjourn

TBX4 Life Symposium (non-UCSF CME activity), Wednesday, March 26, 2025

A full day dedicated to advancing TBX4 research, featuring:

  • Two Translational Science Sessions
  • One Clinical Research Session
  • Invited Talks from established scientists, clinicians, and developing scholars
  • Poster Abstract Exchange during an informal reception

Moderators:
Ripla Arora, PhD
Jeffrey A. Whitsett, MD
Eric D. Austin, MD, MSc

Featured Speaker: Xin Sun, PhD
Professor, Department of Cell and Developmental Biology
University of California, San Diego
 
Registration is free, but limited. Click below for more information:
https://tbx4.org/conference-sf-2025

 

Course Chairs

Jeffrey Fineman, MD
Professor and Vice Chair of Pediatrics
Chief, Division of Critical Care Medicine
Investigator, Cardiovascular Research Institute
Director, Pediatric Pulmonary Hypertension Service
University of California, San Francisco
UCSF Benioff Children's Hospital

Steven Abman, MD
Professor, Department of Pediatrics
Director, Pediatric Heart Lung Center
University of Colorado School of Medicine and Children's Hospital Colorado

Eric D. Austin, MD, MSc
Associate Professor of Pediatrics
Endowed Directorship in Pediatric Pulmonary Hypertension Research
Director, Vanderbilt Pediatric Pulmonary Hypertension Clinical &
Research Program
Director, Vanderbilt M.S. in Clinical Investigation (M.S.C.I.) Training Program
Division of Allergy, Immunology and Pulmonary Medicine
Vanderbilt University School of Medicine

 

Faculty

(University of California, San Francisco unless indicated)

GUEST FACULTY

Gabriel Altit, MDCM
Assistant Professor, Department of Pediatrics, Division of Neonatology
Associate Member to the Division of Experimental Medicine and to the Department of Epidemiology
McGill University Health Centre, Montreal

Maurice Beghetti, MD
Directeur du Centre Universitaire de Cardiologie et Chirurgie Cardiaque Pédiatrique. Congenital Heart Center (CHUV et HUG)
Head of Pediatric Subspecialties Division(HUG)
Head of Pediatric Cardiology Unit (HUG)
Director Pulmonary Hypertension Program (HUG)
Children's University Hospital
University Hospital, Geneva

Rolf Berger, MD, PhD
Professor of Pediatrics
University of Groningen | RUG · Center for Congenital Heart Diseases, Beatrix

Erika Berman-Rosenzweig, MD
Professor of Pediatrics
Director, Pulmonary Hypertension Center
Columbia University, College of Physicians and Surgeons

Michael Cookson, MD
Assistant Professor
University of Colorado & Children’s Hospital Colorado

Paul Critser, MD, PhD
Assistant Professor
Heart Institute, Cincinnati Children's Hospital Medical Center

Vinicio de Jesus Perez, MD
Associate Dean of Stanford MD Admissions and Professor of Medicine (PACCM)
Stanford University School of Medicine

Maria del Cerro, MD
Departamento de Cardiología Pediátrica y Cardiopatías Congénitas
Hospital Universitario Ramón y Cajal

Mark Friedberg, MD, PhD
Professor of Pediatrics, Staff Physician, Hospital for Sick Children
Harvard Medical School

Jose Gomez-Arroyo, MD, PhD
Instructor of Clinical & Internal Medicine
College of Medicine, University of Cincinnati

Stephanie Handler, MD
Associate Professor
Medical College of Wisconsin

Amanda Hauck, MD
Associate Professor of Pediatrics
Northwestern Feinberg School of Medicine

Russel Hirsch, MD
Professor, UC Department of Pediatrics
Cincinnati Children’s Hospital

Dunbar Ivy, MD
Professor of Pediatrics
University of Colorado School of Medicine

Vladimir Kalinichenko, MD, PhD
Director, Phoenix Children’s Research Institute
University of Arizona College of Medicine-Phoenix

Usama Kanaan, MD
Associate Professor, Emory University School of Medicine
Director, Pulmonary Hypertension Program
Children's Healthcare of Atlanta

Darrell N. Kotton, MD
Professor of Medicine, Center Director
Boston University and Boston Medical Center

Usha S. Krishnan, MD
Professor, Pediatrics
Columbia University Vagelos College of Physicians and Surgeons

Philip Levy, MD
Physician in Medicine, Division of Newborn Medicine
Associate Professor of Pediatrics
Harvard Medical School

Roberto F. Machado, MD
Dr. Calvin H. English Professor of Medicine, Chief, Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine
Indiana University Department of Medicine

Cedric Manlhiot, PhD
Scientist
The Hospital for Sick Children, Toronto

Kimberley Miles, MD
Pulmonary Hypertension Fellow
Cincinnati Children’s Hospital Medical Center

Shahin Moledina, MD
Consultant Paediatric Cardiologist
Lead Clinician
National Paediatric Pulmonary Hypertension Service UK

Anton Morkin
Founder and CEO, TBX4Life

Edward E. Morrisey, PhD
Robinette Foundation Professor of Cardiovascular Medicine
University of Pennsylvania

Mary Mullen, MD, PhD
Director, Pulmonary Hypertension Service
Senior Associate Cardiologist, Department of Cardiology
Associate Professor of Pediatrics
Harvard Medical School

Darren Orbach, MD, PhD
Sage Schermerhorn Chair in Image-Guided Therapy
Co-Director,  Cerebrovascular Surgery and Interventions Center
Chief, Neurointerventional Radiology
Boston Children’s Hospital / Harvard Medical School
President, World Federation of Interventional & Therapeutic Neuroradiology (WFITN)

Lance S. Prince, MD, PhD
Philip Sunshine, MD Professor in Neonatology
Professor of Pediatrics
Chief of Neonatal and Developmental Medicine
Stanford University School of Medicine

Soni S. Pullamsetti, PhD
Professor
Cardio Pulmonary Institute

Usha Raj, MD, MHA
Anjuli S. Nayak Endowed Professor of Pediatrics
Professor of Pharmacology; Professor of Physiology; Professor of Anatomy and Cell Biology, University of Illinois at Chicago
Adjunct Assistant Professor of Bioengineering, Northwestern University
Adjunct Professor of Public Health, Jodhpur University, India, Department of Pediatrics, University of Illinois

Edda Spiekerkoetter, MD
Associate Professor of Medicine
Pulmonary, Allergy, and Critical Care Medicine
Medical Director, Stanford Hereditary Hemorrhagic Telangiectasia (HHT) Center of Excellence
Co-Associate Director of PSTP Admissions
Stanford University School of Medicine

Elizabeth S. Taglauer, MD, PhD
Assistant Professor of Pediatrics
Boston University Chobanian & Avedisian School of Medicine
Attending Neonatologist, Boston Medical Center

Bernard Thébaud, MD, PhD
Neonatologist, Department of Pediatrics
The Ottawa Hospital and the Children's Hospital of Eastern Ontario

Nidhy P. Varghese, MD
Associate Professor of Pediatrics, Pulmonology; Medical Director
Texas Children’s Hospital Pulmonary Hypertension Center

Jeffrey Whitsett, MD
Institute Co-Director, Perinatal Institute
Section Chief, Division of Neonatology, Perinatal and Pulmonary Biology
Professor, UC Department of Pediatrics

Roham T. Zamanian, MD, FCCP
Professor of Medicine
Stanford University School of Medicine

UCSF FACULTY (Department of Medicine unless otherwise indicated)

Aaron Bodansky, MD
Assistant Professor, Pediatrics

Sanjeev Datar, MD, PhD
Professor, Pediatrics

Roberta L. Keller, MD
Professor of Pediatrics

Tippi C. MacKenzie, MD
Professor of Surgery, Benioff UCSF Professor in Children's Health
Director, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF
Co-Director, Center for Maternal-Fetal Precision Medicine
John G. Bowes Distinguished Professor in Stem Cell and Tissue Biology

Hythem Nawaythou, MD
Associate Professor of Pediatrics, Division of Cardiology

Marc Simon, MD
Director, Pulmonary Vascular Disease and Pulmonary Hypertension Clinic

Mike Smith, MD
Assistant Professor

Stephanie M. Tsoi, MD
Clinical Fellow, Pediatrics

 

 

 

Travel & Lodging

Hilton San Francisco Financial District 
750 Kearney Street, San Francisco, CA 94108
Hotel Phone: (415) 433-6600 / Reservations: 800-424-8292
Rates: $229/night Single/Double Occupancy
Cutoff Date: March 6, 2025

Group Reservations

Air Travel

UNITED AIRLINES
UCSF has negotiated special fares with United Airlines for our course attendees. Download Online Booking Instructions (.pdf)
Code ZQBU296187

Hilton SF

 


Registration Fees

 Early Bird
By 1/31/25
Regular Fee
After 1/31/25
Late Fee
After 3/27/2025
Physician/Scientists$645$695$745
Advanced Practice Professionals/Nurses$545$595$645
Residents/Fellows/Students/Trainees$300$350$400
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PPHNet Members

$545 PPHNet Members

OPTIONAL WORKSHOP:
$125 - Childhood Pulmonary Vascular (Workshop 3/27/2025)
Unraveling the Relevance of Developmental Pathways to Pulmonary Vascular Disease for Therapeutic Development

Registration Instructions: After adding the main course to your cart, you will have the option to add the Childhood Pulmonary Vascular Workshop.

Cancellation Policy

Cancellations received in writing before the first day of the course will be refunded, less an administrative fee of $100. No refunds will be made on cancellations received after that date. Please submit your cancellation request at https://tiny.ucsf.edu/cmehelp


Exhibitors

Exhibit Fee: $3,000
Email Contact for Exhibits [email protected]

Exhibit Description

The exhibit fee includes:

  • 6’ x 30” tabletop exhibit space at UCSF assigned location in exhibit area;
  • Standard acknowledgement from the podium;                  
  • Acknowledgement in the course syllabus distributed to each attendee;
  • Representative/attendees and a copy of the electronic course syllabus.

Exhibit Hours

(subject to updating)

Thursday 3/27/2025 (Workshop PreConference)
7:00 - 8:00AM Continental Breakfast in Exhibit Area
9:50 - 10:00AM Coffee Break in Exhibit Area
2:30 - 2:40PM Coffee Break in Exhibit Area

Friday 3/28/2025
7:00 - 7:45AM Continental Breakfast in Exhibit Area
10:15 - 10:30 Coffee Break in Exhibit Area
3:30 - 3:45PM Coffee Break in Exhibit Area

Saturday 3/29/2025
6:30 - 7:00AM Continental Breakfast in Exhibit Area
10:30 - 10:45AM Coffee Break in Exhibit Area

 

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